Publications Scientifiques

La reconnaissance des contributions de la plateforme de microscopie photonique de la faculté de médecine dans vos publications est grandement appréciée.
La mention des équipements que vous avez utilisés dans la section Matériels et Méthodes démontre la contribution de la plateforme à la communauté universitaire et permet d'évaluer l'impact de chaque équipement sur l'infrastructure de recherche.

Langlois MJ, Servant R, Reyes-Nicolas V, Jones C, Roy SA, Paquet M, Carrier JC, Rivard N, Boudreau F, Perreault N.
Loss of PTEN signaling in Foxl1+ mesenchymal telocytes initiates spontaneous colonic neoplasia in mice.
Cell Mol Gastroenterol Hepatol. 2019 May 27. pii: S2352-345X(19)30069-4.

Babeu JP, Wilson SD, Lambert É, Lévesque D, Boisvert FM, Boudreau F.
Quantitative Proteomics Identifies DNA Repair as a Novel Biological Function for Hepatocyte Nuclear Factor 4α in Colorectal Cancer Cells.
Cancers (Basel). 2019 May 5;11(5).

Li X, Rosciglione S, Laniel A, Lavoie C.
Combining RNAi and Immunofluorescence Approaches to Investigate Post-endocytic Sorting of GPCRs into Multivesicular Bodies.
Methods Mol Biol. 2019;1947:303-322.

Génier S, Degrandmaison J, Lavoie CL, Gendron L, Parent JL.
Monitoring the Aggregation of GPCRs by Fluorescence Microscopy.
Methods Mol Biol. 2019;1947:289-302.

Malette J, Degrandmaison J, Giguère H, Berthiaume J, Frappier M, Parent JL, Auger-Messier M, Boulay G.
MURC/CAVIN-4 facilitates store-operated calcium entry in neonatal cardiomyocytes.
Biochim Biophys Acta Mol Cell Res. 2019 Aug;1866(8):1249-1259.

Gonneaud A, Turgeon N, Jones C, Couture C, Lévesque D, Boisvert FM, Boudreau F, Asselin C.
HDAC1 and HDAC2 independently regulate common and specific intrinsic responses in murine enteroids.
Sci Rep. 2019 Mar 29;9(1):5363.

Girard R, Darsigny M, Jones C, Maloum-Rami F, Gélinas Y, Carpentier AC, Laplante M, Perreault N, Boudreau F.
HNF4α is a novel regulator of intestinal glucose-dependent insulinotropic polypeptide.
Sci Rep. 2019 Mar 12;9(1):4200.

Lapointe F, Turcotte S, Véronneau S, Rola-Pleszczynski M, Stankova J.
Role of Protein Tyrosine Phosphatase Epsilon (PTPε) in Leukotriene D4-Induced CXCL8 Expression.
J Pharmacol Exp Ther. 2019 May;369(2):270-281.

Denhez B, Rousseau M, Dancosst DA, Lizotte F, Guay A, Auger-Messier M, Côté AM, Geraldes P.
Diabetes-Induced DUSP4 Reduction Promotes Podocyte Dysfunction and Progression of Diabetic Nephropathy.
Diabetes. 2019 May;68(5):1026-1039.

Del Olmo T, Lauzier A, Normandin C, Larcher R, Lecours M, Jean D, Lessard L, Steinberg F, Boisvert FM, Jean S.
APEX2-mediated RAB proximity labeling identifies a role for RAB21 in clathrin-independent cargo sorting.
EMBO Rep. 2019 Feb;20(2).

Gagné-Sansfacon J, Langlois A, Langlois MJ, Coulombe G, Tremblay S, Vaillancourt-Lavigueur V, Qu CK, Menendez A, Rivard N.
The tyrosine phosphatase Shp-2 confers resistance to colonic inflammation by driving goblet cell function and crypt regeneration.
J Pathol. 2019 Jan;247(1):135-146.

Beaudry K, Langlois MJ, Montagne A, Cagnol S, Carrier JC, Rivard N.
Dual-specificity phosphatase 6 deletion protects the colonic epithelium against inflammation and promotes both proliferation and tumorigenesis.
J Cell Physiol. 2019 May;234(5):6731-6745.

Giguère H, Dumont AA, Berthiaume J, Oliveira V, Laberge G, Auger-Messier M.
ADAP1 limits neonatal cardiomyocyte hypertrophy by reducing integrin cell surface expression.
Sci Rep. 2018 Sep 11;8(1):13605.

Dion SP, Béliveau F, Morency LP, Désilets A, Najmanovich R, Leduc R.
Functional diversity of TMPRSS6 isoforms and variants expressed in hepatocellular carcinoma cell lines.
Sci Rep. 2018 Aug 22;8(1):12562.

Babeu JP, Jones C, Geha S, Carrier JC, Boudreau F.
P1 promoter-driven HNF4α isoforms are specifically repressed by β-catenin signaling in colorectal cancer cells.
J Cell Sci. 2018 Jul 6;131(13).

Harper K, R Lavoie R, Charbonneau M, Brochu-Gaudreau K, Dubois CM.
The Hypoxic Tumor Microenvironment Promotes Invadopodia Formation and Metastasis through LPA1 Receptor and EGFR Cooperation.
Mol Cancer Res. 2018 Oct;16(10):1601-1613.

Abdallah K, Nadeau F, Bergeron F, Blouin S, Blais V, Bradbury KM, Lavoie CL, Parent JL, Gendron L.
Adeno-associated virus 2/9 delivery of Cre recombinase in mouse primary afferents.
Sci Rep. 2018 May 9;8(1):7321.

Paquette M, Beaudoin S, Tremblay MA, Jean S, Lopez AF, Lecomte R, Guérin B, Bentourkia M, Sabbagh R, Leyton JV.
NLS-Cholic Acid Conjugation to IL-5Rα-Specific Antibody Improves Cellular Accumulation and In Vivo Tumor-Targeting Properties in a Bladder Cancer Model.
Bioconjug Chem. 2018 Apr 18;29(4):1352-1363.

Charfi I, Abdallah K, Gendron L, Pineyro G.
Delta opioid receptors recycle to the membrane after sorting to the degradation path.
Cell Mol Life Sci. 2018 Jun;75(12):2257-2271.

Massonneau J, Ouellet C, Lucien F, Dubois CM, Tyler J, Boissonneault G.
Suboptimal extracellular pH values alter DNA damage response to induced double-strand breaks.
FEBS Open Bio. 2018 Feb 16;8(3):416-425.

Placet M, Arguin G, Molle CM, Babeu JP, Jones C, Carrier JC, Robaye B, Geha S, Boudreau F, Gendron FP.
The G protein-coupled P2Y₆ receptor promotes colorectal cancer tumorigenesis by inhibiting apoptosis.
Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt A):1539-1551.

St-Louis É, Degrandmaison J, Grastilleur S, Génier S, Blais V, Lavoie C, Parent JL, Gendron L.
Involvement of the coatomer protein complex I in the intracellular traffic of the delta opioid receptor.
Mol Cell Neurosci. 2017; 79: 53.

Li X, Létourneau D, Holleran B, Leduc R, Lavigne P, Lavoie C.
Gαs protein binds ubiquitin to regulate epidermal growth factor receptor endosomal sorting.
Proc Natl Acad Sci U S A. 2017; 114: 13477.

Latreille R, Servant R, Darsigny M, Marcoux S, Jones C, Perreault N, Boudreau F.
Transcription factor CUX1 is required for intestinal epithelial wound healing and targets the VAV2-RAC1 Signalling complex.
Biochim Biophys Acta Mol Cell Res. 2017 Dec;1864(12):2347-2355.

Chevrier M, Bobbala D, Villalobos-Hernandez A, Khan MG, Ramanathan S, Saucier C, Ferbeyre G, Geha S, Ilangumaran S.
Expression of SOCS1 and the downstream targets of its putative tumor suppressor functions in prostate cancer.
BMC Cancer. 2017; 17: 157.

Duclos CM, Champagne A, Carrier JC, Saucier C, Lavoie CL, Denault JB.
Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling.
Cell Death Discov. 2017 ; 3: 16100.

Saint-Germain E, Mignacca L, Vernier M, Bobbala D, Ilangumaran S, Ferbeyre G.
SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes.
Aging (Albany NY). 2017; 9: 2137.

Fujita N, Huang W, Lin TH, Groulx JF, Jean S, Nguyen J, Kuchitsu Y, Koyama-Honda I, Mizushima N, Fukuda M, Kiger AA.
Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy.
Elife. 2017 Jan 7;6.

Mourer T, Normant V, Labbé S.
Heme Assimilation in Schizosaccharomyces pombe Requires Cell-surface-anchored Protein Shu1 and Vacuolar Transporter Abc3.
J Biol Chem. 2017; 292: 4898.

Couture F, Sabbagh R, Kwiatkowska A, Desjardins R, Guay SP, Bouchard L, Day R.
PACE4 Undergoes an Oncogenic Alternative Splicing Switch in Cancer.
Cancer Res. 2017; 77: 6863.

Samandi S, Roy AV, Delcourt V, Lucier JF, Gagnon J, Beaudoin MC, Vanderperre B, Breton MA, Motard J, Jacques JF, Brunelle M, Gagnon-Arsenault I, Fournier I, Ouangraoua A, Hunting DJ, Cohen AA, Landry CR, Scott MS, Roucou X.
Deep transcriptome annotation enables the discovery and functional characterization of cryptic small proteins.
Elife. 2017; 6 pii: e27860.

Gui Y, Khan MGM, Bobbala D, Dubois C, Ramanathan S, Saucier C, Ilangumaran S.
Attenuation of MET-mediated migration and invasion in hepatocellular carcinoma cells by SOCS1. Attenuation of MET-mediated migration and invasion in hepatocellular carcinoma cells by SOCS1.
World J Gastroenterol. 2017; 23: 6639

Hamel-Côté G, Gendron D, Rola-Pleszczynski M, Stankova J.
Regulation of platelet-activating factor-mediated protein tyrosine phosphatase 1B activation by a Janus kinase 2/calpain pathway. Regulation of platelet-activating factor-mediated protein tyrosine phosphatase 1B activation by a Janus kinase 2/calpain pathway.
PLoS One. 2017; 12: e0180336.

Lucien F, Pelletier PP, Lavoie RR, Lacroix JM, Roy S, Parent JL, Arsenault D, Harper K, Dubois CM.
Hypoxia-induced mobilization of NHE6 to the plasma membrane triggers endosome hyperacidification and chemoresistance.
Nat Commun. 2017; 8: 15884.

Serrano D, Ghobadi F, Boulay G, Ilangumaran S, Lavoie C, Ramanathan S.
GTPase of the Immune-Associated Nucleotide Protein 5 Regulates the Lysosomal Calcium Compartment in T Lymphocytes.
Front Immunol. 2017; 8: 94.

Bégin-Lavallée V, Midavaine É, Dansereau MA, Tétreault P, Longpré JM, Jacobi AM, Rose SD, Behlke MA, Beaudet N, Sarret P.
Functional inhibition of chemokine receptor CCR2 by dicer-substrate-siRNA prevents pain development.
Mol Pain. 2016 Jun 15;12.

Gonneaud A, Turgeon N, Boudreau F, Perreault N, Rivard N, Asselin C.
Distinct Roles for Intestinal Epithelial Cell-Specific Hdac1 and Hdac2 in the Regulation of Murine Intestinal Homeostasis.
J Cell Physiol. 2016 Feb;231(2):436-48.

Bian B, Mongrain S, Cagnol S, Langlois MJ, Boulanger J, Bernatchez G, Carrier JC, Boudreau F, Rivard N.
Cathepsin B promotes colorectal tumorigenesis, cell invasion, and metastasis.
Mol Carcinog. 2016 May;55(5):671-87.

Coulombe G, Langlois A, De Palma G, Langlois MJ, McCarville JL, Gagné-Sanfaçon J, Perreault N, Feng GS, Bercik P, Boudreau F, Verdu EF, Rivard N.
SHP-2 Phosphatase Prevents Colonic Inflammation by Controlling Secretory Cell Differentiation and Maintaining Host-Microbiota Homeostasis.
J Cell Physiol. 2016 Nov;231(11):2529-40.

Gagné-Sansfaçon J, Coulombe G, Langlois MJ, Langlois A, Paquet M, Carrier J, Feng GS, Qu CK, Rivard N.
SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development.
Oncotarget. 2016 Oct 4;7(40):65676-65695.

Lepage D, Bélanger É, Jones C, Tremblay S, Allaire JM, Bruneau J, Asselin C, Perreault N, Menendez A, Gendron FP, Boudreau F.
Gata4 is critical to maintain gut barrier function and mucosal integrity following epithelial injury.
Sci Rep. 2016 Nov 9;6:36776.

Roy SA, Allaire JM, Ouellet C, Maloum-Rami F, Pomerleau V, Lemieux É, Babeu JP, Rousseau J, Paquet M, Garde-Granger P, Boudreau F, Perreault N.
Loss of mesenchymal bone morphogenetic protein signaling leads to development of reactive stroma and initiation of the gastric neoplastic cascade.
Sci Rep. 2016 Sep 9;6:32759.

Allaire JM, Roy SA, Ouellet C, Lemieux É, Jones C, Paquet M, Boudreau F, Perreault N.
Bmp signaling in colonic mesenchyme regulates stromal microenvironment and protects from polyposis initiation.
Int J Cancer. 2016 Jun 1;138(11):2700-12.

Génier S, Degrandmaison J, Moreau P, Labrecque P, Hébert TE, Parent JL.
Regulation of GPCR expression through an interaction with CCT7, a subunit of the CCT/TRiC complex.
Mol Biol Cell. 2016 Dec 1;27(24):3800-3812. Epub 2016 Oct 5.

Charbonneau M, Lavoie RR, Lauzier A, Harper K, McDonald PP, Dubois CM.
Platelet-Derived Growth Factor Receptor Activation Promotes the Prodestructive Invadosome-Forming Phenotype of Synoviocytes from Patients with Rheumatoid Arthritis.
J Immunol. 2016 Apr 15;196(8):3264-75.

Lauzier A, Lavoie RR, Charbonneau M, Gouin-Boisvert B, Harper K, Dubois CM.
Snail Is a Critical Mediator of Invadosome Formation and Joint Degradation in Arthritis.
Am J Pathol. 2016 Feb;186(2):359-74.

Larkin H, Costantino S, Seaman MN, Lavoie C.
Calnuc Function in Endosomal Sorting of Lysosomal Receptors.
Traffic. 2016 Apr;17(4):416-32.